Mobilization of mercury by DMPS in occupationally exposed workers and in model experiments on rats: evaluation of body burden.
Identifieur interne : 000527 ( Main/Exploration ); précédent : 000526; suivant : 000528Mobilization of mercury by DMPS in occupationally exposed workers and in model experiments on rats: evaluation of body burden.
Auteurs : J. Nerudová [République tchèque] ; Z. Cábelková ; E. Frantík ; E. Lukás ; P. Urban ; K. Bláha ; D. Pelclová ; J. Lebedová ; M. CikrtSource :
- International journal of occupational medicine and environmental health [ 1232-1087 ] ; 2000.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de variance (MeSH), Animaux (MeSH), Charge corporelle (MeSH), Chélateurs (usage thérapeutique), Femelle (MeSH), Humains (MeSH), Intoxication au mercure (métabolisme), Intoxication au mercure (traitement médicamenteux), Maladies professionnelles (métabolisme), Maladies professionnelles (traitement médicamenteux), Mâle (MeSH), Rat Wistar (MeSH), Rats (MeSH), Unithiol (usage thérapeutique), Études cas-témoins (MeSH).
- MESH :
- métabolisme : Intoxication au mercure, Maladies professionnelles.
- traitement médicamenteux : Intoxication au mercure, Maladies professionnelles.
- usage thérapeutique : Chélateurs, Unithiol.
- Adulte, Adulte d'âge moyen, Analyse de variance, Animaux, Charge corporelle, Femelle, Humains, Mâle, Rat Wistar, Rats, Études cas-témoins.
English descriptors
- KwdEn :
- Adult (MeSH), Analysis of Variance (MeSH), Animals (MeSH), Body Burden (MeSH), Case-Control Studies (MeSH), Chelating Agents (therapeutic use), Female (MeSH), Humans (MeSH), Male (MeSH), Mercury Poisoning (drug therapy), Mercury Poisoning (metabolism), Middle Aged (MeSH), Occupational Diseases (drug therapy), Occupational Diseases (metabolism), Rats (MeSH), Rats, Wistar (MeSH), Unithiol (therapeutic use).
- MESH :
- chemical , therapeutic use : Chelating Agents, Unithiol.
- drug therapy : Mercury Poisoning, Occupational Diseases.
- metabolism : Mercury Poisoning, Occupational Diseases.
- Adult, Analysis of Variance, Animals, Body Burden, Case-Control Studies, Female, Humans, Male, Middle Aged, Rats, Rats, Wistar.
Abstract
The aim of the study was to evaluate the efficacy of DMPS (sodium-2,3-dimercapto-1-propane sulfonate) (Dimaval) administration for mobilizing mercury from the body in occupationally exposed people and experimental animals. Two doses of DMPS were administered at a 24-h interval to: (a) groups of people occupationally exposed to merkury--workers of the chloralkali industry (n = 43), and dentists (n = 12), (b) non-exposed individuals (n = 20), and (c) rats chronically exposed to mercury vapour at the concentration of 0.8 mg/m3 Hg degree (6 h/day, 5 days/week) for 15 weeks. In an out-patient mobilizing test, the urinary excretion of mercury 48 h after the administration of the first dose reached 1513 micrograms in the group of industrial workers, 132.6 micrograms in dentists, and 3.78 micrograms in controls. In rats, two consecutive doses of DMPS decreased kidney content of mercury by about 30% and 50% after oral and intraperitoneal administration, respectively. Kidney mercury burden was calculated on the basis of the data from animal and human studies of the mobilization of mercury via urine after DMPS treatment: 61, 2800 and 28,000 ng/g in controls, dentists and workers, respectively. It was estimated that two doses of DMPS mobilized 17-20% (after oral administration) and 25-30% (after intramuscular administration) of kidney mercury burden, both in the control and exposed subjects.
PubMed: 10967843
Affiliations:
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Nerudová</name><affiliation wicri:level="3"><nlm:affiliation>Centre of Industrial Health and Occupational Diseases, National Institute of Public Health, Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>Centre of Industrial Health and Occupational Diseases, National Institute of Public Health, Prague</wicri:regionArea><placeName><settlement type="city">Prague</settlement><region type="région" nuts="2">Bohême centrale</region></placeName></affiliation></author><author><name sortKey="Cabelkova, Z" sort="Cabelkova, Z" uniqKey="Cabelkova Z" first="Z" last="Cábelková">Z. Cábelková</name></author><author><name sortKey="Frantik, E" sort="Frantik, E" uniqKey="Frantik E" first="E" last="Frantík">E. Frantík</name></author><author><name sortKey="Lukas, E" sort="Lukas, E" uniqKey="Lukas E" first="E" last="Lukás">E. Lukás</name></author><author><name sortKey="Urban, P" sort="Urban, P" uniqKey="Urban P" first="P" last="Urban">P. Urban</name></author><author><name sortKey="Blaha, K" sort="Blaha, K" uniqKey="Blaha K" first="K" last="Bláha">K. Bláha</name></author><author><name sortKey="Pelclova, D" sort="Pelclova, D" uniqKey="Pelclova D" first="D" last="Pelclová">D. Pelclová</name></author><author><name sortKey="Lebedova, J" sort="Lebedova, J" uniqKey="Lebedova J" first="J" last="Lebedová">J. Lebedová</name></author><author><name sortKey="Cikrt, M" sort="Cikrt, M" uniqKey="Cikrt M" first="M" last="Cikrt">M. Cikrt</name></author></analytic><series><title level="j">International journal of occupational medicine and environmental health</title><idno type="ISSN">1232-1087</idno><imprint><date when="2000" type="published">2000</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term><term>Analysis of Variance (MeSH)</term><term>Animals (MeSH)</term><term>Body Burden (MeSH)</term><term>Case-Control Studies (MeSH)</term><term>Chelating Agents (therapeutic use)</term><term>Female (MeSH)</term><term>Humans (MeSH)</term><term>Male (MeSH)</term><term>Mercury Poisoning (drug therapy)</term><term>Mercury Poisoning (metabolism)</term><term>Middle Aged (MeSH)</term><term>Occupational Diseases (drug therapy)</term><term>Occupational Diseases (metabolism)</term><term>Rats (MeSH)</term><term>Rats, Wistar (MeSH)</term><term>Unithiol (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term><term>Adulte d'âge moyen (MeSH)</term><term>Analyse de variance (MeSH)</term><term>Animaux (MeSH)</term><term>Charge corporelle (MeSH)</term><term>Chélateurs (usage thérapeutique)</term><term>Femelle (MeSH)</term><term>Humains (MeSH)</term><term>Intoxication au mercure (métabolisme)</term><term>Intoxication au mercure (traitement médicamenteux)</term><term>Maladies professionnelles (métabolisme)</term><term>Maladies professionnelles (traitement médicamenteux)</term><term>Mâle (MeSH)</term><term>Rat Wistar (MeSH)</term><term>Rats (MeSH)</term><term>Unithiol (usage thérapeutique)</term><term>Études cas-témoins (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chelating Agents</term><term>Unithiol</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Mercury Poisoning</term><term>Occupational Diseases</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Mercury Poisoning</term><term>Occupational Diseases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Intoxication au mercure</term><term>Maladies professionnelles</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Intoxication au mercure</term><term>Maladies professionnelles</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Chélateurs</term><term>Unithiol</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Animals</term><term>Body Burden</term><term>Case-Control Studies</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Analyse de variance</term><term>Animaux</term><term>Charge corporelle</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Rat Wistar</term><term>Rats</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aim of the study was to evaluate the efficacy of DMPS (sodium-2,3-dimercapto-1-propane sulfonate) (Dimaval) administration for mobilizing mercury from the body in occupationally exposed people and experimental animals. Two doses of DMPS were administered at a 24-h interval to: (a) groups of people occupationally exposed to merkury--workers of the chloralkali industry (n = 43), and dentists (n = 12), (b) non-exposed individuals (n = 20), and (c) rats chronically exposed to mercury vapour at the concentration of 0.8 mg/m3 Hg degree (6 h/day, 5 days/week) for 15 weeks. In an out-patient mobilizing test, the urinary excretion of mercury 48 h after the administration of the first dose reached 1513 micrograms in the group of industrial workers, 132.6 micrograms in dentists, and 3.78 micrograms in controls. In rats, two consecutive doses of DMPS decreased kidney content of mercury by about 30% and 50% after oral and intraperitoneal administration, respectively. Kidney mercury burden was calculated on the basis of the data from animal and human studies of the mobilization of mercury via urine after DMPS treatment: 61, 2800 and 28,000 ng/g in controls, dentists and workers, respectively. It was estimated that two doses of DMPS mobilized 17-20% (after oral administration) and 25-30% (after intramuscular administration) of kidney mercury burden, both in the control and exposed subjects.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">10967843</PMID><DateCompleted><Year>2000</Year><Month>09</Month><Day>19</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1232-1087</ISSN><JournalIssue CitedMedium="Print"><Volume>13</Volume><Issue>2</Issue><PubDate><Year>2000</Year></PubDate></JournalIssue><Title>International journal of occupational medicine and environmental health</Title><ISOAbbreviation>Int J Occup Med Environ Health</ISOAbbreviation></Journal><ArticleTitle>Mobilization of mercury by DMPS in occupationally exposed workers and in model experiments on rats: evaluation of body burden.</ArticleTitle><Pagination><MedlinePgn>131-46</MedlinePgn></Pagination><Abstract><AbstractText>The aim of the study was to evaluate the efficacy of DMPS (sodium-2,3-dimercapto-1-propane sulfonate) (Dimaval) administration for mobilizing mercury from the body in occupationally exposed people and experimental animals. Two doses of DMPS were administered at a 24-h interval to: (a) groups of people occupationally exposed to merkury--workers of the chloralkali industry (n = 43), and dentists (n = 12), (b) non-exposed individuals (n = 20), and (c) rats chronically exposed to mercury vapour at the concentration of 0.8 mg/m3 Hg degree (6 h/day, 5 days/week) for 15 weeks. In an out-patient mobilizing test, the urinary excretion of mercury 48 h after the administration of the first dose reached 1513 micrograms in the group of industrial workers, 132.6 micrograms in dentists, and 3.78 micrograms in controls. In rats, two consecutive doses of DMPS decreased kidney content of mercury by about 30% and 50% after oral and intraperitoneal administration, respectively. Kidney mercury burden was calculated on the basis of the data from animal and human studies of the mobilization of mercury via urine after DMPS treatment: 61, 2800 and 28,000 ng/g in controls, dentists and workers, respectively. It was estimated that two doses of DMPS mobilized 17-20% (after oral administration) and 25-30% (after intramuscular administration) of kidney mercury burden, both in the control and exposed subjects.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nerudová</LastName><ForeName>J</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Centre of Industrial Health and Occupational Diseases, National Institute of Public Health, Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cábelková</LastName><ForeName>Z</ForeName><Initials>Z</Initials></Author><Author ValidYN="Y"><LastName>Frantík</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Lukás</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Urban</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Bláha</LastName><ForeName>K</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Pelclová</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Lebedová</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Cikrt</LastName><ForeName>M</ForeName><Initials>M</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Poland</Country><MedlineTA>Int J Occup Med Environ Health</MedlineTA><NlmUniqueID>9437093</NlmUniqueID><ISSNLinking>1232-1087</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002614">Chelating Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>4076-02-2</RegistryNumber><NameOfSubstance UI="D014494">Unithiol</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001822" MajorTopicYN="N">Body Burden</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016022" MajorTopicYN="N">Case-Control Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002614" MajorTopicYN="N">Chelating Agents</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008630" MajorTopicYN="N">Mercury Poisoning</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009784" MajorTopicYN="N">Occupational Diseases</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014494" MajorTopicYN="N">Unithiol</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2000</Year><Month>9</Month><Day>1</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2000</Year><Month>9</Month><Day>23</Day><Hour>11</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2000</Year><Month>9</Month><Day>1</Day><Hour>11</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">10967843</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République tchèque</li></country><region><li>Bohême centrale</li></region><settlement><li>Prague</li></settlement></list><tree><noCountry><name sortKey="Blaha, K" sort="Blaha, K" uniqKey="Blaha K" first="K" last="Bláha">K. Bláha</name><name sortKey="Cabelkova, Z" sort="Cabelkova, Z" uniqKey="Cabelkova Z" first="Z" last="Cábelková">Z. Cábelková</name><name sortKey="Cikrt, M" sort="Cikrt, M" uniqKey="Cikrt M" first="M" last="Cikrt">M. Cikrt</name><name sortKey="Frantik, E" sort="Frantik, E" uniqKey="Frantik E" first="E" last="Frantík">E. Frantík</name><name sortKey="Lebedova, J" sort="Lebedova, J" uniqKey="Lebedova J" first="J" last="Lebedová">J. Lebedová</name><name sortKey="Lukas, E" sort="Lukas, E" uniqKey="Lukas E" first="E" last="Lukás">E. Lukás</name><name sortKey="Pelclova, D" sort="Pelclova, D" uniqKey="Pelclova D" first="D" last="Pelclová">D. Pelclová</name><name sortKey="Urban, P" sort="Urban, P" uniqKey="Urban P" first="P" last="Urban">P. Urban</name></noCountry><country name="République tchèque"><region name="Bohême centrale"><name sortKey="Nerudova, J" sort="Nerudova, J" uniqKey="Nerudova J" first="J" last="Nerudová">J. 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